Reading DNA differently: what AlphaGenome changes
At the intersection of artificial intelligence and biology, a new way to investigate gene regulation is emerging.
Google DeepMind
AlphaGenome analyses DNA sequences of up to one million base pairs and predicts properties related to gene regulation. Introduced in 2025, the research was published in Nature in January 2026.
By comparing original and altered sequences, the model helps researchers investigate the possible effects of genetic variants. It supports hypothesis generation; it is not a clinical diagnosis.
The focus extends beyond protein-coding regions. Regulatory regions also shape cellular activity. Models like this help scientists explore those relationships and prioritise experiments.
Original sourceGoogle DeepMind · Nature